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The open-source XSLT implementation is based around a core framework which is open for extension and customisation.This paper introduces the Schematron language and the available implementations.While negative inotropism may precipitate or exacerbate heart failure, certain beta blockers (e.g.carvedilol, bisoprolol and metoprolol) have been believed to reduce morbidity and mortality in congestive heart failure.

These channels respond to voltage changes across the membrane differently: L-type channels respond to higher membrane potentials, open more slowly, and remain open longer than T-type channels.

Positively inotropic agents increase the strength of muscular contraction.

The term inotropic state is most commonly used in reference to various drugs that affect the strength of contraction of heart muscle (myocardial contractility).

Because of these properties, L-type channels are important in sustaining an action potential, while T-type channels are important in initiating them.

By increasing intracellular calcium, via the action of the L-type channels, the action potential can be sustained for longer and therefore, contractility increases.

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An overview of the architecture, with a view to producing customised versions is also provided.

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